Bringing together researchers building agents that pose scientific questions, run computational experiments, and update their conclusions as new evidence comes in.
Scientific discovery proceeds through repeated cycles of gathering evidence, proposing hypotheses, and testing them against observations. Scientific agents offer a way to coordinate these steps — connecting scientific literature and databases with computational analysis, simulation, and experimental validation, and using each result to guide the next investigation.
This workshop focuses on scientific inquiry conducted through digital environments, where agents interact with scientific knowledge and software to pursue a research objective. These environments let agents explore candidate explanations, conduct controlled computational tests, and examine results before committing to further investigation. We ask how agents can connect scientific reasoning with executable tests, reason about the limits of simulators and learned models, respond to unexpected observations, and preserve the rationale behind earlier decisions in multi-stage investigations.
How can agents use digital environments to produce findings that are scientifically meaningful and independently verifiable?
How should agents combine literature, structured scientific data, and domain knowledge to formulate hypotheses with traceable evidence?
How should agents plan retrieval, simulations, and experiments under uncertainty and resource constraints — and decide when a hypothesis needs revision?
How should evaluation connect the quality of individual agent decisions with scientific validity, novelty, reproducibility, and discovery efficiency?
We invite submissions on agents that pose scientific questions, run computational experiments, and update their conclusions as new evidence comes in. Research papers, position papers, work-in-progress papers, and demos are all welcome, whether the focus is on methods or on applications to problems from any field of science.
All deadlines are 11:59 PM Anywhere on Earth (AoE).
Topics include, but are not limited to:
sigconf), as used by WSDM 2027.Submissions are handled through Microsoft CMT.
Keynote talks spanning AI for science, agent auditing, and personalized agent systems.
Reach out to the organizing team — we are happy to hear from authors, speakers, and sponsors.